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Just In! Coming Soon Cardiac Imaging Cardiac Nursing Cardiac Surgery Cardiology (Assorted) Echo (Clinical) ECG Electrophysiology Fellows Heart Rhythm Society Interventional IBHRE (NASPExAM®) Prep Pacing & ICDs Cardiology - Clearance Browse All Subjects Cardiology (Assorted) Arrhythmia Cardiac Surgery Cardiovascular Diseases ECG Electrophysiology Heart Failure Interventional Pacing & ICDs Pediatric Vascular Diseases Just In! Coming Soon Computed Tomography Diagnostic Imaging (Assorted) Echo Tech MRI Test Prep (Self-assessment) Ultrasound Imaging - Clearance Browse All Subjects Diagnostic Imaging (Assorted) Computed Tomography Doppler Echocardiography Imaging - Test Prep MRI Nuclear Physics TEE Ultrasound Great Gift Idea! Give the gift of Cardiotext Sign up for free e-mail news about new titles and sales.	Product Detail Approaches to High Throughput Toxicity Screening Edited by: C. K. Atterwill; Edited by: P. Goldfarb Cardiotext Price: $179.95 Availability: Processing time varies. Price is tentative. Alert me when this product is available Availability Questions? Product Information: ISBN-13: 9780748407521 ISBN-10: 0748407529 Publisher: Informa Healthcare Format: Hardback Pub Date: 12/1999 Edition Number: 1 Shipping Calculator Request a Quote for 10+ Copies Tell A Friend Synopsis The toxicology of safety testing of new pharmaceutical medicines using in vitro cell culture systems as animal alternatives in an important new science. The recent application of molecular biology (or toxicogenomics) to toxicity testing has enabled more accurate prediction of safety using in vitro systems and high throughput screening systems. These screening systems can be automated to provide fast, cost-effective and more ethical approaches to toxicity screening. Toxicogenomics is the study of organ and cellular responses to toxicity in terms of cellular stress gene induction. This family of genes (or stress gene `fingerprints') may in future allow accurate prediction of human hazard at low doses of compounds using human cell-bases systems. The recent development of gene expression microarrays (GEMs) in-situ based assays for stress gene induction using gene-probes (e.g. scintillation proximity assays and reporter gene technology) and organotypic culture systems (e.g. liver and brain spenoids) has and will enable automation and miniturisation of toxicogenomic-based high throughput screens in toxicology and drug metabolism. This book takes an integrated approach to in vitro toxicology and ADME screening using these new technologies and discusses how they might be applied to the pre-clinical safety assessment and `lead optimisation' of new pharmaceutical products in drug discovery. Edited and written by leading authorities in the field, this practical and comprehensive volume will be valuable reading for postgraduate and professional toxicologists and pre-clinical scientists in academia, contract testing organisations and the chemical and pharmaceutical industries. Customer Reviews Be the first to review this product Browse Titles In Related Subjects
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