This monograph is a valuable multidisciplinary resource, written by experts in the fields of mechanical and electrical engineering, pathology, neurology, imaging, clinical and vascular biology, physics, radiology and surgery. The book's nineteen chapters and five transcribed Panel Discussions provides a wealth of information on the identification and treatment of atherosclerotic plaques, including the latest diagnostic applications of numerous imaging techniques, the reasons for selecting a particular method, and what can be learned from the imaging results. Important insights into the structural and cellular components of vulnerable plaque are presented, as well as an examination of factors/activities that trigger thrombosis.
Contributors.
Chapter 1. Evolving Concepts of Atherothrombosis (Valentin Fuster, MD, PhD and Roberto Corti, MD).
Chapter 2. Cerebrovascular Diseases: Pathophysiology and Management (Debabrata Mukherjee, MD and Jay S. Yadav, MD).
Chapter 3. Aortic Arch Vulnerable Plaques: Update (Pierre Amarenco, MD and Ariel Cohen, MD, PhD).
Chapter 4. The Vulnerable Atherosclerotic Plaque in Peripheral Vascular Disease (Michael L. Marin, MD, Larry H. Hollier, MD, Valentin Fuster, MD, PhD, and Jeffrey Goldman, MD) .
Panel Discussion I. Overview of Pathology: Clinical Correlations of Atherosclerosis.
Chapter 5. Thermography: A Novel Approach for Identification of Plaques at Risk of Rupture and/or Thrombosis (Mohammad Madjid, MD, Morteza Naghavi, MD, James T. Willerson, MD, and Ward Casscells, MD).
Chapter 6. Intravascular Ultrasound and Plaque Vulnerability: Evidence of a Systemic Disease Process (Paul Schoenhagen, MD and Steven E. Nissen, MD, FACC).
Chapter 7. Intracoronary Angioscopy to Detect Vulnerable Plaques: A Technique Whose Time Has Come? (Sergio Waxman, MD).
Chapter 8. Electron Beam Computed Tomography in Assessing the Vulnerable Atherosclerotic Plaque (Robert A. O'Rourke, MD).
Chapter 9. Multirow-Detector Helical Computed Tomography (Christoph R. Becker, MD, Uwe J. Schoepf, MD, and Maximilian F. Reiser, MD) .
Panel Discussion IIA. Overview of Imaging: Coronary Atherosclerosis.
Chapter 10. Imaging of the High-Risk Plaque Using Magnetic Resonance Imaging (Zahi A. Fayad, PhD and Valentin Fuster, MD, PhD).
Chapter 11. Cardiovascular Imaging with Optical Coherence Tomography (Mark E. Brezinski, MD, PhD and James Fujimoto, PhD) .
Panel Discussion IIB. Overview of Imaging: Atherosclerotic Regions and Imaging Modalities.
Chapter 12. Plaque Instability and Remodeling: Mechanisms and Possible Misconceptions (Trine-Line Korsholm, MS, Gerard Pasterkamp, MD, PhD, MSc, and Erling Falk, MD, PhD).
Chapter 13. Structural and Cellular Components of the Vulnerable Plaque: Extracellular Matrix (Renu Virmani, MD, Frank D. Kolodgie, PhD, Allen P. Burke, MD, Andrew Farb, MD, and Thomas N. Wight, PhD).
Chapter 14. Structural and Cellular Components of the Vulnerable Plaque: Inflammatory Cells (Allard C. van der Wal, MD, PhD, Mischa A. Houtkamp, MSc, Onno J. de Boer, PhD, and Anton E. Becker, MD, PhD) .
Panel Discussion III. Structural and Cellular Components of the Vulnerable Atherosclerotic Plaque.
Chapter 15. Stress and Strain: Biomechanical Guides for Imaging Plaque Stability (Hayden Huang, DSc and Richard T. Lee, MD).
Chapter 16. Endothelium, Flow, and Atherothrombosis (Roberto Corti, MD, Lina Badimon, PhD, Valentin Fuster, MD, PhD, and Juan Jose Badimon, PhD).
Chapter 17. Activities that Trigger Plaque Disruption (Jagmeet P. Singh, MD, DM, PhD, James Januzzi, MD, and James E. Muller, MD) .
Panel Discussion IV. Mechanical Forces in Plaque Disruption.
Chapter 18. Matrix Metalloproteinases and Their Inhibitors (Uwe Sch önbeck, PhD and Peter Libby, MD).
Chapter 19. Calcium Deposition in Vulnerable Atherosclerotic Plaques: Pathophysiologic Mechanisms and Potential Implications in the Acute Coronary Syndromes (Pedro R. Moreno, MD) .
Panel Discussion V. Regulation of Functional Components of the Vulnerable Plaque.
Index.