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Atlas of Heart Failure: Cardiac Function and Dysfunction
Wilson S. Colucci; Eugene Braunwald

Atlas of Heart Failure: Cardiac Function and Dysfunction Retail Price: $125.00
Cardiotext Price: $122.50

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Product Information:
ISBN-13: 9781573401845
ISBN-10: 1573401846
Publisher: CURRENT MEDICINE, INC
Format: Hardcover, 296 pages
Pub Date: 06/2002
Edition Number: 3


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Synopsis

Cardiovascular medicine is one of the most 'visual' of medical specialities. Cardiovascular diagnosis is based on the recognition and understanding of a variety of graphic waveforms, images, decision trees, and microscopic sections. Treatment increasingly involves the use of algorithms which are also most effectively portrayed visually. Likewise, mechanical correction of cardiovascular disorders, whether catheter based or surgical, can best be described pictorially.

This atlas has been designed to provide a detailed and comprehensive visual exposition of all aspects of cardiac function and dysfunction. Several hundred images, accompanied by detailed captions, have been carefully selected by expert authors and reviewed by the editor.

This volume addresses normal cardiac function, mechanisms of dysfunction in heart failure, and therapeutic approaches to managing the syndrome.




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Additional Description

CONTENTS
CHAPTER 1
MOLECULAR AND CELLULAR BASIS OF
CONTRACTION
Arnold M. Katz
Structure 2
Contraction and Relaxation 6
Cellular Regulation 14
Growth Regulation 17
CHAPTER 2
PHYSIOLOGY OF MYOCARDIAL
CONTRACTION
Mark R. Starling
Mechanics of Cardiac Contraction 20
Determinants of Contraction in the Intact Heart 23
Preload 25
Contractility 28
Afterload 29
Myocardial Energetics 31
Neural Control of Contractility 33
CHAPTER 3
THE ETIOLOGIC BASIS OF CONGESTIVE HEART
FAILURE
Joshua M. Hare
Etiology and Epidemiology 38
Heart Failure Associated With Coronary Disease 39
Heart Failure Associated With Valvular Lesions 41
Idiopathic Dilated Cardiomyopathy 43
Inflammatory Diseases of the Myocardium 44
Secondary Causes of Cardiomyopathy 50
Infiltrative/Restrictive Cardiomyopathies 58
Hypertrophic Cardiomyopathy 60
Right Ventricular Cardiomyopathy 61
CHAPTER 4
MOLECULAR AND CELLULAR EVENTS IN
MYOCARDIAL HYPERTROPHY AND FAILURE
Douglas B. Sawyer and Wilson S. Colucci
Ventricular Remodeling 66
Molecular and Cellular Phenotypes 67
Calcium Handling and Contractile Protein Expression 70
Cell Death 73
Cell Replacement 76
Extracellular Matrix 77
(3-Adrenergic Pathway 79
Renin-Angiotensin System, Endothelin, and Inflammatory
Cytokines 80
Oxidative Stress 83
CHAPTER 5 CARDIAC REMODELING AND ITS
PREVENTION
Marc A. Pfeffer
Cardiac Growth and Remodeling 88
Early Remodeling After Myocardial Infarction and Infarct
Expansion 90
Remodeling and Prognosis 92
Progressive Enlargement After Myocardial Infarction 93
Modification of Remodeling After Myocardial Infarction
95
CHAPTER 6 NEUROHUMORAL, RENAL, AND
VASCULAR ADJUSTMENTS IN HEART FAILURE
Anju Nohria, Jorge A. Cusco, and Mark A. Creager
Mechanisms in Heart Failure 104
Sympathetic Nervous System 104
The Renin-Angiotensin-Aldosterone System 110
The Arginine-Vasopressin System 114
Natriuretic Peptides 116
Local Mechanisms 119
Regional Blood Flow 124
CHAPTER 7 ASSESSMENT OF HEART FAILURE
James B. Young
Overview 128
Assessing the Patient 130
Diagnostic Tests 139
Designing a Therapeutic Plan 142
CHAPTER 8
PROGNOSTIC INDICATORS AND ASSESSMENT OF
THERAPEUTIC RESPONSES
Henry Ooi and Jay N. Cohn
Mortality in Patients With Heart Failure 146
Use of Prognostic Variables 149
Assessment of Therapeutic Responses 154
CHAPTER 9UNSTABLE HEART FAILURE
Carl V Leier and David A. Orsinelli
Acute Heart Failure 162
Decompensated Chronic Heart Failure 171
CHAPTER 10 DIGITALIS AND DIURETICS
D. Bradley S. Dyke and Robert j. Cody
Diuretics 180
Digoxin 185
CHAPTER 11 ANGIOTENSIN-CONVERTING ENZYME
INHIBITION AND ANGIOTENSIN RECEPTOR
BLOCKADE
Todd M. Koelling and Robert j. Cody
Angiotensin-converting Enzyme Inhibitors 194
Angiotensin Receptor Blockers 204
CHAPTER 12
(3-BLOCKERS
Michael M. Givertz and Wilson S. Colucci
CHAPTER 13
NEW APPROACHES TO THE TREATMENT OF HEART
FAILURE
Michael M. Givertz and Wilson S. Colucci
Neurohormonal Antagonists 224
Inotropic Agents 231
Resynchronization Therapy 232
Novel Biologic Therapies for Myocardial Recovery 234
CHAPTER 14 CARDIAC TRANSPLANTATION
Donna Mancini and Mat Williams
Posttransplantation Survival 240
Candidate Selection 240
Donor Selection Criteria 243
Surgical Techniques 244
Allograft Rejection 246
Quality of Life After Transplantation 250
Accelerated Transplantation Atherosclerosis and
Retransplantation 251
Mechanical-assist Devices 252
CHAPTER 15 DIASTOLIC DYSFUNCTION:
PATHOPHYSIOLOGY, CLINICAL FEATURES, AND
TREATMENT
Carl S. Apstein
Normal Diastolic Function 260
Pathophysiology of LV Diastolic Dysfunction 267
Diastolic Dysfunction with Ischemia, Hypertrophy, and
Other Causes 271
Aging and Diastolic Dysfunction 277
Clinical Features, Prognosis, and Treatment 282
INDEX 1.1



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