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In this timely volume, Drs. Dzau and Liew – both pioneers in the area – help cardiologists understand: • how cardiovascular genetics may remodel the way cardiovascular medicine is practiced • what material has immediate relevance to the practicing clinician • how to incorporate genetics and genomics in your practice to ensure up-to-date patient care
The book opens with introductory chapters, then discusses: • cardiovascular single gene disorders • cardiovascular polygenic disorders • therapies and applications
Outstanding contributors write on their areas of expertise, making Cardiovascular Genetics and Genomics for the Cardiologist both authoritative and comprehensive. If you want to gain a better appreciation of how genetics and genomics are already shaping current practice and may potentially revolutionize cardiology, look no further than this dependable reference.
Foreword.
Introduction.
1 The gene in the twenty-first century.
Choong-Chin Liew, Victor J. D zau .
Part I: Cardiovascular single gene disorders .
2 Monogenic hypercholesterolemia.
Ruth McPherson.
3 Hypertrophic cardiomyopathy.
Ali J. Marian .
4 Dilated cardiomyopathy and other cardiomyopathies.
Mitra Esfandiarei, Robert Yanagawa, Bruce M. McManus.
5 The long QT syndrome.
Sabina Kupershmidt, Kamilla Kelemen, Tadashi Nakajima .
Part II: Cardiovascular polygenic disorders.
6 Atherosclerosis.
P äivi Pajukanta, Kiat Tsong Tan, Choong-Chin Liew.
7 Heart failure.
Markus Meyer, Peter VanBuren .
8 The implications of genes on the pathogenesis, diagnosis and therapeutics of hypertension.
Kiat Tsong Tan, Choong-Chin Liew .
Part III: Therapies and applications.
9 Gene therapy for cardiovascular disease: inserting new genes, regulating the expression of native genes, and correcting genetic defects.
Ion S. Jovin, Frank J. Giordano .
10 Stem cell therapy for cardiovascular disease.
Emerson C. Perin, Guilherme V. Silva .
11 Pharmacogenetics and personalized medicine.
Julie A. Johnson, Issam Zineh .
12 The potential of blood-based gene profiling for disease assessment.
Steve Mohr, Choong-Chin Liew .
Index.
Colour plates