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TABLE OF CONTENTS
Introduction: Cardiac Signs and Symptoms 1
James T. Willerson
1. Congenital Heart Disease in the Adult 31
Anatomic Abnormalities 31
Jack L. Titus and Jesse E. Edwards
Pathophysiology, Clinical Recognition,
and Treatment 67
Yang Wang
Echocardiography 128
David S. Bach and William F Armstrong
Surgical Treatment 154
Magdi Yacoub, John R. Pepper and Rosemary
Radley-Smith
2. Valvular Heart Disease 173
Anatomic Abnormalities 173
Hugh A. McAllister Jr, L. Maximilian Buja, and
Victor J. Ferrans
Aortic Valve Disease 187
Otto M. Hess, Urs Scherrer and Pascal Nicod
Pulmonary and Tricuspid Valve Disease 198
Otto M. Hess, Urs Scherrer and Pascal Nicod
Mitral Valve Disease 202
Otto M. Hess, Urs Scherrer Pascal Nicod, and
Elliot Chesler
Combined Valvular Disease 225
Otto M. Hess, Urs Scherrer and Pascal Nicod
Acute Rheumatic Fever 227
Robert D. Leachman and D. Richard Leachman
Infective Endocarditis 240
Walter R. Wilson and Francis T. Thandroyen
Cardiac Catheterization 256
Yang Wang
Echocardiography and Doppler Evaluation 276
William F Armstrong
Nuclear Cardiology 295
A. Iain McGhie
Surgical Treatment 299
Denton A. Cooley, O. H. Frazier and
Michael S. Sweeney
3. Coronary Artery Disease 315
Anatomic Abnormalities 316
L. Maximilian Buja and Hugh A. McAllister Jr.
Pathophysiology and Clinical Recognition 333
James T. Willerson, Lawrence S. Cohen, and
Attilio Maseri
Silent Myocardial Ischemia 366
Neil S. Kleiman
Angina Pectoris in Patients With Normal Coronary
Angiograms 375
Neil S. Kleiman
Coronary Angiography 390
Robert F. Wilson and Carl W. White
Echocardiography 464
Francis T. Thandroyen
Nuclear Cardiology 475
A. Iain McGhie, K Lance Gould, Heinrich R.
Schelbert, and James T. Willerson
Natural History 527
Chuichi Kawai and Yasuyuki Nakamura
Medical Treatment 544
James T. Willerson, Attilio Maseri, Peter Sleight,
and Burton E. Sobel
Mechanical Devices 617
H. Vernon Anderson, Richard W. Smalling, and
Patrick W. Serruys
Surgical Treatment 652
Michael S. Sweeney, O. H. Frazier and
Denton A. Cooley
Coronary Artery Bypass Surgery and Percutaneous
Transluminal Coronary Angioplasty 670
James J. Ferguson and James M. Wilson
Rehabilitation 702
George C. Haidet
4. Basic Aspects of Myocardial Function, Growth,
and Development 741
Cardiac Growth and Development 741
Eric N. Olson, James F. Martin, and
Michael D. Schneider
Myocardial Metabolism 752
Heinrich Taegtmeyer
Cardiac Hypertrophy and Failure 771
Bernard Swynghedauw and Edouard Coraboeuf
Regulation of Cardiac Contraction and
Relaxation 790
Arnold M. Katz
Clinical Abnormalities of Cardiac Relaxation 803
Beverly H. Lorell
5. Myocardial Disease 817
Anatomic Abnormalities 818
Hugh A. McAllister Jr., L. Maximilian Buja, and
Victor J. Ferrans
Dilated Cardiomyopathy 832
John F. Goodwin
Hypertrophic Cardiomyopathy 852
E. Douglas Wigle
Restrictive Cardiomyopathy 871
John F. Goodwin
Other Cardiomyopathies 888
James T. Willerson
Myocarditis 894
R. Douglas Ensley, Dale C. Renlund, and
Jay W. Mason
Cardiac Catheterization in Cardiomyopathy 924
James J. Ferguson
Echocardiography in Cardiomyopathy 934
Francis T. Thandroyen and Michael Adams
Nuclear Cardiology 942
A. Iain McGhie
Heart Failure 947
Jay N. Cohn
Surgical Treatment of Advanced Heart Failure 979
O. H. Frazier, Michael P. Macris,
Denton A. Cooley, and Michael S. Sweeney
Medical Treatment of the Heart Transplant
Recipient 993
Spencer H. Kubo
Rejection of the Transplanted Heart: Recognition
and Potential New Treatments 1005
James T. Willerson
6. Pericardial Disease 1007
Anatomic Abnormalities 1007
Hugh A. McAllister, Jr, L. Maximilian Buja, and
Victor J. Ferrans
Etiology, Pathophysiology, Clinical Recognition,
and Treatment 1011
Ralph Shahetai
7. Vascular Medicine 1041
Vascular Muscle Structure and Function 1042
David R. Hathaway, Leonard P. Adam,
Robert L. Wilensky, and Keith L. March
Circulatory Regulation: Basic Considerations 1053
John T. Shepherd, Thomas F. Luscher,
and Giuseppe Mancia
Circulatory Regulation: The Role of Vascular
Structural Remodeling 1067
Victor J. Dzau
Vascular Endothelial Cell Function
and Thrombosis 1080
H. Roger Lijnen and Desire Collen
Basic Mechanisms of Atherosclerosis 1090
L. Maximilian Buja
Atherosclerosis: Pathogenesis and Risk Factors 1101
John A. Farmer and Antonio M. Gotto, Jr.
Diseases of the Aorta 1113
James T. Willerson, Bharat Raval,
Michael S. Sweeney, and O. H. Frazier
Peripheral Vascular Diseases 1162
Thom W. Rooke and Alan T. Hirsch
B-Mode Ultrasound: A Noninvasive Method for
Assessing Atherosclerosis 1182
Curt D. Furberg, Robert P. Byington,
and Ward Riley
Intravascular Ultrasound: Background and
Development 1188
Paul G. Yock and Peter J. Fitzgerald
Intravascular Ultrasound: Clinical
Applications 1195
James J. Ferguson
Vascular Compliance 1212
Gary E. McVeigh, Alan J. Bank, and Jay N. Cohn
Hypertension 1228
Bernard Waeber, Hans R. Brunner, Michel Burnier
and Jay N. Cohn
Autonomic Dysfunction, Hypertension,
and Shock 1263
Christopher J. Mathias and Rolf M. Gunnar
8. Electrical Disturbances of the Heart 1281
Recognition and Physiologic Treatment of Cardiac
Arrhythmias and Conduction Disturbances 1282
Gerald V. Naccarelli, James T. Willerson,
and C. Gunnar Blomqvist
Sinus Node Dysfunction 1296
David G. Benditt
Atrioventricular Nodal and Subnodal Conduction
Disturbances 1316
Hein J.J. Wellens
Supraventricular Tachycardias 1327
Hein J.J. Wellens
Pre-Excitation 1343
Hein J.J. Wellens
Atrial Fibrillation 1355
Gerald V. Naccarelli
Ventricular Arrhythmia Disturbances
and Sudden Cardiac Death 1369
Gerald V. Naccarelli
Wide QRS Tachycardia 1393
Hein J.J. Wellens
Syncope 1404
David G. Benditt
Anti-Arrhythmic Drugs 1421
Gerald V. Naccarelli
Implantable Cardioverter/Difibrillators 1441
Gerald V. Naccarelli
Catheter Ablation for the Treatment of
Tachyarrhythmias 1453
Gerald V. Naccarelli
Surgical Treatment of Arrhythmias 1476
T. Bruce Ferguson, Jr., and James L. Cox
9. Pulmonary Hypertension 1495
E. Kenneth Weir, Stephen L. Archer and
Lewis J. Rubin
10. Tumors of the Heart 1525
Robert J. Hall, Hugh A. McAllister Jr.,
Denton A. Cooley, and L. Maximilian Buja
11. Aging and the Cardiovascular System 1539
Gary Gerstenblith and Edward G. Lakatta
12. Pregnancy and the Heart 1551
Susan D. Mueller and James T. Willerson
13. Endocrine Disorders and the Heart 1607
Victor R. Lavis, Susan D. Mueller and
James T. Willerson
14. The Genetic Basis for Cardiovascular
Disease 1633
Classification of Genetic Disorders 1633
Dianna Milewicz
Inherited Disorders of Connective Tissue 1638
Dianna Milewicz
Muscular Dystrophies Affecting the Heart 1647
C. Thomas Caskey
Genetic Aspects of Congenital Heart Disease 1656
Dianna Milewicz
15. Connective Tissue Diseases and
the Heart 1665
Frank C. Arnett and James T. Willerson
16. Substance Abuse and the Heart 1687
Eric J. Eichhorn and Paul A. Grayburn
17. Cardiovascular Involvement in the Acquired
Immunodeficiency Syndrome 1703
Melvin D. Cheitlin and Merle A. Sande
18. Coronary Artery Disease in Women 1715
Anne L. Taylor and Susan D. Mueller
19. Neuromuscular Disorders and
Heart Disease 1727
Joseph Lee and Shilpesh Patel
20. Cardiovascular Changes Associated With
Space Flight 1745
Dominick D'Aunno, Mary Lou Roper and
Michael W. Bungo
21. Newer Imaging Modalities 1757
Rapid-Speed Computed Tomography 1757
Bruce H. Brundage
Magnetic Resonance 1766
Craig R. Malloy and Ronald M. Peshock
22. Evaluation of Patients for Noncardiac
Surgery 1781
Sumita D. Paul and Kim A. Eagle
23. Anesthesia for Cardiovascular
Operations 1795
John R. Cooper Jr. and N. Martin Giesecke
24. Preventive Cardiology 1809
Coronary Risk Factors: An Overview 1809
William B. Kannel
Smoking 1829
John A. Oates and Craig R. Heim
Hypertension 1835
Norman M. Kaplan
Cholesterol 1846
Scott M. Grundy
Obesity 1865
James K. Alexander
Exercise 1872
Benjamin D. Levine, Daniel B. Friedman,
C. Gunnar Blomqvist, and Jere H. Mitchell
Gene Therapy 1884
Elizabeth G. Nabel and Gary J. Nabel
25. Hematologic Diseases and Heart
Disease 1893
James T. Willerson
26. Exercise Testing 1901
A. Iain McGhie and James T. Willerson
Index 1905
Color plates follow page 128.
