The advent of multidetector computed tomography (MDCT) using 64 detector rows and beyond provides the next leap forward in cardiovascular care, delivering on the promise of high-resolution visualization of cardiovascular structure and function noninvasively. The goal of this text is to demonstrate the clinical context within which this technology is useful for individual patient assessment, providing some technic al information needed to perform cardiovascular CTA but primarily focused on the spectrum of clinical applications. Practicing clinicians know that patient care without technology is feasible, but medical technology applied without clinical acumen is, at best, irrelevant. Thus, in preparing this text the authors sought to demonstrate the application of cardiovascular multidetector computed tomography from the perspective of patient care.