This new edition covers important new trials in cardiology therapies and prevention of cardiovascular problems. The world authorities on pharmacologic clinical trials write about the trials, the outcomes and importance for clinical practice. This book gives the general cardiologist insight into the development of new therapies in cardiology as well as the process of how trials were used for those therapies. In addition to providing a manual for how to establish trials, trials for treatment and prevention are covered.

Key Features

Evidence-based research to guide clinical practice.

Coverage of treatment trials including Glycoprotein IIb/IIa receptor inhibitors, aspirin, drug therapies for arrhythmias, and pacing.

Expanded section on prevention of cardiac disease

Covers both prevention and treatment.

By JoAnn Manson, MD, DrPH, Professor of Medicine, Harvard Medical School; Chief, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA; Julie E. Buring, ScD, Professor of Ambulatory Care and Prevention, Harvard Medical School; Deputy Director, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA; Paul M. Ridker, MD, MPH, Associate Professor of Medicine, Harvard Medical School Director of the Center for Cardiovascular Disease Prevention, Director of Cardiovascular Disease Research, Co-Director of Blood Studies, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard School of Medicine, Brigham and Women's Hospital, Boston, MA; and J. Michael Gaziano, MD, MPH, Associate Professor of Medicine, Harvard Medical School, Co-Director of Cardiovascular Disease Research and Co-Director of Blood Studies, Division of Preventive Medicine, Brigham and Women's Hospital, Preventive Medicine Division, Boston, MA