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TABLE OF CONTENTS
FOREWORD 1
INTRODUCTION 3
The 4 domains and 4 eras of pediatric cardiology
Pioneers
Interaction of tools and concepts
The child with heart disease
A: PATHOLOGIC ANATOMY, THE PRE-THERAPEUTIC ERA
1 PRIOR TO WILLIAM HARVEY 13
Growth of knowledge of the two circulations
Aristotle and the embryonic heart
Preventive cardiology?
The child with heart disease
2 FROM HARVEY TO THE MID 19th CENTURY 23
The two centuries from Harvey to Peacock
Pathologic anatomy of specific defects
New tools, the microscope, sphygmomanometer,
stethoscope
Concepts of blood pressure, cyanosis, murmurs
Early descriptions of how heart problems affect
the child
3 LATE 19th EARLY 20th CENTURY 33
The 80 years from Peacock to Abbott
New tools, Xray, EKG, fluoroscope
Clinical profile of specific defects
(Roget, Fallot, Abbott)
Embryologic advances
The child with heart disease
B: THERAPEUTIC ERA CLINICOPHYSIOLOGIC CORRELATIONS, SURGERY
4 THE DAWN OF THERAPY, 1930s-1955 47
Closed heart surgery (PDA/Blalock Taussig
shunt/coarctation) Role of fluoroscopy
Tools of cardiac catheterization, angiocardiography
Interaction of clinicophysiologic concepts and surgery
5 OPEN HEART SURGERY 1955-MID 1970s 65
Cardiopulmonary bypass: concepts and tools
Surgical advances, new pathologic insights
Rashkind atrial septostomy
Rheumatic heart disease
Mitral valve prolapse
The pioneer patient
C: INFANT CARDIOLOGY ERA
6 INFANT ERA 1970s TO 1990 87
Modern times: concepts of neonatal cardiology
Tools: pharmacologic manipulation of ductus
Doppler echocardiography
Infant heart surgery
Pulmonary valvuloplasty; invasive cardiology
Kawasaki disease: cardiomyopathy: arrhythmia
Two young women with palpitations
7 DEVELOPMENT OF PEDIATRIC CARDIOLOGY 115
History of 3 specific defects: tetralogy; VSD, double
inlet ventricle
Growth of the discipline of pediatric cardiology
Geographic history
D: DEVELOPMENTAL ERA: PERSPECTIVES
8 DEVELOPMENTAL ERA THE 1990s AND BEYOND 141
Studies in cardiac development
Preventive approaches: closing the circle
9 ETHICS AND PUBLIC POLICY 153
The frontiers of cardiovascular treatment and prevention
Therapy: changing ethical issues
Molecular biology, screening, the fetal heart
INDEX 161


