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TABLE OF CONTENTS
1. A Review of the Biological Significance of Carbohydrates on
Glycoproteins and Methods for Their Analysis 1
R.P. Dennis
2. The Different Faces of Disease: FACED Diagnosis of Disease 13
J.C. Klock and C.M. Starr
3. Chemometrics of Oligosaccharide Analysis: Parameterization of
HPLC of PA-Oligosaccharides 27
Y.C. Lee and N. Takahashi
4. Molecular Modelling of Glycoproteins by Homology with
Non-Glycosylated Protein Domains, Computer Simulated
Glycosylation and Molecular Dynamics 37
D.V. Renouf and E.F. Hounsell
5. Control and Function of Complex-Type Oligosaccharide
Synthesis: Novel Variants of the LacNAc Pathway 47
D.H. Van den Eijnden, A.P. Neeleman, W.P.W. Van der Knaap,
H. Bakker, Marja Agterberg, and I. Van Die
6. The Regulation of Cell- and Tissue-Specific Expression of
Glycans by Glycosyltransferases 53
A. Dinter and E.G. Berger
7. The Genetic Regulation of Sialyl-LeX Expression in
Hemopoietic Cells 83
W. M. Watkins, P.O. Skacel, and J.L. Clarke
8. Murine B1,4-Galactosyltransferase: Analysis of a Gene that
Serves both a Housekeeping and a Cell Specific Function 95
J.H. Shaper, A. Harduin-Lepers, B. Rajput, and N.L. Shaper
9. Cell Surface B1 ,4-Galactosyltransferase: A Signal
Transducing Receptor? 105
D.H. Dubois and B.D. Shur
10. O-Linked N-Acetylglucosamine: The "Yin-Yang" of Ser/Thr
Phosphorylation?: Nuclear and Cytoplasmic Glycosylation 115
G.W. Hart, K.D. Greis, L.-Y.D. Dong, M.A. Blomberg,
T.-Y. Chou, M.-S. Jiang, E.P. Roquemore, D.M. Snow,
L.K. Kreppel, R.C. Cole, F.I. Comer, C.S. Arnold, and
B.K. Hayes
11. Heparan Sulphate and Protein Recognition: Binding
Specificities and Activation Mechanisms 125
J.T. Gallagher
12. Glycosylation and Maturation Rate of Membrane and Secretory
Forms of Human CD8a Glycoprotein: Implications in the
Activation of T-Lymphocytes 135
F. Serafini-Cessi, G. Martire, N. Malagolini, M.C. Pascale,
M.C. Erra, and S. Bonatti
13. Lectin-Carbohydrate Interactions in Disease: T-Cell
Recognition of IgA and IgD; Mannose Binding Protein
Recognition of IgG0 147
P. Rudd, F. Fortune, T. Lehner, R. Parekh, T. Patel,
M. Wormald, R. Malhotra, R. Sim, and R. Dwek
14. Glycosylation of Antibody Molecules: A Small Step for
Structure, a Leap for Function 153
R. Jefferis, M. Goodall, V. Tishchenko, P. Nash, and J. Lund
15. The Effects of Altered Glycosylation of IgG on Rheumatoid
Factor-Binding and Immune Complex Formation 155
A.J. Soltys, A. Bond, O.M.R. Westwood, and F.C. Hay
16. Agalactosylation by Reactive Oxygen Species and Fc Related
Changes to Function 161
H.R. Griffiths and J. Lunec
17. An Introduction to Glycosylation and Rheumatic Disease: What
Is the Current State of Play? 171
J.S. Axford and A. Alavi
18. Abnormalities in the Glycosylation of IgG and Its Clinical
Utility 179
D. Isenberg
19. B1 ,4-Galactosyltransferase Variations in Rheumatoid
Arthritis 185
A. Alavi and J.S. Axford
20. Significance and Molecular Basis for IgG Glycosylation
Changes in Rheumatoid Arthritis 193
T.W. Rademacher, R.H.V. Jones, and P.J. Williams
21. Immunology of Chondroitin/Dermatan Sulfate 205
V.C. Hascall, R.J. Midura, J.M. Sorrell, and A.H.K. Plaas
22. IgA Glycosylation and Disease 217
M. Dueymes, D. Baharaki, J. Cledes, Y.L. Pennec, and
P. Youinou
23. IgA Nephropathy: A Disease of Incomplete IgA 1
Glycosylation? 221
M. Tomana, B.A Julian, F.B Waldo, R. Kulhavy, and
J. Mestecky
24. a1-Acid Glycoprotein: A Natural Occurring Anti-Inflammatory
Molecule? 223
W. van Dijk
25. Haptoglobin: A Potential Reporter Molecule for Glycosylation
Changes in Disease 231
G.A. Turner
26. Inflammatory Cytokines Controlling Branching of
N-Heteroglycans of Acute Phase Protein 239
K. Gryska, A. Slupianek, M. Laciak, A. Gorny, K. Mackiewicz,
H. Baumann, A. Mackiewicz
27. Cell Cycle-Related Protein Kinases and T Cell Death 247
J.M. Lahti, J. Xiang, and V.J. Kidd
28. Sialomucins in Inflammation and Hematopoiesis 259
L.A. Lasky
29. Synthesis and Biological Activity of Oligosaccharide
Libraries 261
Y. Ding, O. Kanie, J. Labbe, M.M. Palcic, B. Ernst, and
O. Hindsgaul
30. In Vivo Targeting Function of N-Linked Oligosaccharides:
Pharmacokinetic and Biodistribution of N-Linked
Oligosaccharides 271
Kevin G. Rice, Ming Chiu, Manpreet S. Wadhwa,
V. Hayden Thomas, and Hilary J. Stubbs
31. Studies on Selectin-Carbohydrate Interactions 283
G.S. Jacob, J.K. Welply, P.R. Scudder, C. Kirmaier,
S. Zaheer Abbas, S.C. Howard, J.L. Keene, J.J. Schmuke,
K. Broschat, and C. Steininger
Index 291
