Harrison's Principles of Internal Medicine, 17th Edition Anthony S. Fauci; Eugene Braunwald Retail Price: $199.00 Cardiotext Price: $195.02 Availability: In stock. Usually ships within 24 hours. Rush shipping available. Product Information: ISBN-13: 9780071466332 ISBN-10: 0071466339 Publisher: McGraw-Hill Professional Format: Mixed media Pub Date: 03/2008 Edition Number: 17 Shipping Calculator Request a Quote for 10+ Copies Tell A Friend

Contents

Contributors

Preface

Part 1

Introduction to Clinical Medicine

1 The Practice of Medicine The Editors

2 Global Issues in Medicine Jim Yong Kim / Paul Farmer

3 Decision-Making in Clinical Medicine Daniel B. Mark

4 Screening and Prevention of Diseases Gary J. Martin

5 Principles of Clinical Pharmacology Dan M. Roden

6 Women’s Health Andrea Dunaif

7 Medical Disorders during Pregnancy Robert L. Barbieri / John T. Repke

8 Medical Evaluation of the Surgical Patient Wei C. Lau / Kim A. Eagle

9 Geriatric Medicine Lisa B. Caruso / Rebecca A. Silliman

10 Complementary and Alternative Medicine Stephen E. Straus

11 Palliative and End-of-Life Care Ezekiel J. Emanuel / Joshua Hauser / Linda L. Emanuel

e1 The Safety and Quality of Health Care David W. Bates

e2 Economic Considerations in the Practice of Medicine David Meltzer

e3 Racial and Ethnic Disparities in Health Care Joseph R. Betancourt / David Blumenthal

e4 Ethical Issues in Clinical Medicine Bernard Lo

Part 2

Cardinal Manifestations and Presentation of Diseases

Section 1

Pain

12 Pain: Pathophysiology and Management Howard L. Fields / Joseph B. Martin

13 Chest Discomfort Thomas H. Lee

14 Abdominal Pain William Silen

15 Headache Peter J. Goadsby / Neil H. Raskin

16 Back and Neck Pain John W. Engstrom

Section 2

Alterations in Body Temperature

17 Fever and Hyperthermia Charles A. Dinarello / Reuven Porat

18 Fever and Rash Elaine T. Kaye / Kenneth M. Kaye

e5 Atlas of Rashes Associated with Fever Elaine T. Kaye / Kenneth M. Kaye

19 Fever of Unknown Origin Jeffery A. Gelfand / Michael V. Callahan

20 Hypothermia and Frostbite Daniel F. Danzl

Section 3

Nervous System Dysfunction

21 Syncope Mark D. Carlson

22 Dizziness and Vertigo Robert B. Daroff

23 Weakness and Paralysis Michael J. Aminoff

24 Gait and Balance Disorders Lewis Sudarsky

25 Numbness, Tingling, and Sensory Loss Michael J. Aminoff / Arthur K.Asbury

26 Confusion and Delirium S. Andrew Josephson / Bruce L. Miller

e6 Memory Loss Thomas D. Bird / Bruce L. Miller

27 Aphasia, Memory Loss, and Other Focal Cerebral Disorders M.-Marsel Mesulam

28 Sleep Disorders Charles A. Czeisler / John W. Winkleman / Gary S. Richardson

Section 4

Disorders of Eyes, Ears, Nose, and Throat

29 Disorders of the Eye Jonathan C. Horton

30 Disorders of Smell, Taste, and Hearing Anil K. Lalwani

31 Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Infecti ons Michael A. Rubin / Ralph Gonzales / Merle A. Sande

32 Oral Manifestations of Disease Samuel C. Durso

e7 Atlas of Oral Manifestations of Disease Samuel C. Durso / Janet A. Yellowitz

Section 5

Alterations in Circulatory and Respiratory Functions

33 Dyspnea and Pulmonary Edema Richard M. Schwartzstein

34 Cough and Hemoptysis Steven E. Weinberger / David A. Lipson

35 Hypoxia and Cyanosis Eugene Braunwald

36 Edema Eugene Braunwald / Joseph Loscalzo

e8 Approach to the Patient with a Heart Murmur Patrick O’Gara / Eugene Braunwald

37 Palpitations Joseph Loscalzo

Section 6

Alterations in Gastrointestinal Function

38 Dysphagia Raj K. Goyal

39 Nausea, Vomiting, and Indigestion William L. Hasler

40 Diarrhea and Constipation Michael Camilleri / Joseph A. Murray

41 Weight Loss Carol M. Reife

42 Gastrointestinal Bleeding Loren Laine

43 Jaundice Daniel S. Pratt / Marshall M. Kaplan

44 Abdominal Swelling and Ascites Robert M. Glickman / Roshini Rajapaksa

Section 7

Alterations in Renal and Urinary Tract Function

45 Azotemia and Urinary Abnormalities Bradley M. Denker / Barry M. Brenner

e9 Atlas of Urinary Sediments and Renal Biopsies Agnes B. Fogo / Eric G. Neilsen

46 Fluid and Electrolyte Disturbances Gary G. Singer / Barry M. Brenner

47 Hypercalcemia and Hypocalcemia Sundeep Khosla

48 Acidosis and Alkalosis Thomas B. DuBose, Jr.

Section 8

Alterations in Sexual Function and Reproduction

49 Sexual Dysfunction Kevin T. McVary

50 Hirsutism and Virilization David A. Ehrmann

51 Menstrual Disorders and Pelvic Pain Janet E. Hall

Section 9 Alterations in the Skin

52 Approach to the Patient with a Skin Disorder Thomas J. Lawley / Kim B. Yancey

53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders Calvin O. McCall / Thomas J. Lawley

54 Skin Manif estations of Internal Disease Jean L. Bolognia / Irwin M. Braverman

55 Immunologically Mediated Skin Diseases Kim B. Yancey / Thomas J. Lawley

56 Cutaneous Drug Reactions Jean-Claude Roujeau / Robert S. Stern / Bruce C. Wintroub

57 Photosensitivity and Other Reactions to Light David R. Bickers

e10 Atlas of Skin Manifestations of Internal Disease Thomas J. Lawley / Stephen Templeton

Section 10

Hematologic Alterations

58 Anemia and Polycythemia John W. Adamson / Dan L. Longo

59 Bleeding and Thrombosis Barbara A. Konkle

60 Enlargement of Lymph Nodes and Spleen Patrick H. Henry / Dan L. Longo

61 Disorders of Granulocytes and Monocytes Steven M. Holland /John I. Gallin

e11 Atlas of Hematology and Analysis of Peripheral Blood Smears Dan L. Longo

Part 3 Genetics and Disease

62 Principles of Human Genetics J. Larry Jameson / Peter Kopp

63 Chromosome Disorders Terry Hassold / Stuart Schwartz

64 The Practice of Genetics in Clinical Medicine Susan Miesfeldt / J. Larry Jameson

65 Gene Therapy in Clinical Medicine Katherine A. High

Part 4

Regenerative Medicine

66 Stem Cell Biology Minoru S. H. Ko

67 Applications of Stem Cell Biology in Clinical Medicine Jack A. Kessler

68 Hematopoietic Stem Cells David T. Scadden / Dan L. Longo

69 Tissue Engineering Jennifer Anderson /Joseph P. Vacanti

Part 5

Nutrition

70 Nutritional Requirements and Dietary Assessment Johanna Dwyer

71 Vitamin and Trace Mineral Deficiency and Excess Robert M. Russell / Paolo M. Suter

72 Malnutrition and Nutritional Assessment Douglas C. Heimburger

73 Enteral and Parenteral Nutrition Therapy Bruce R. Bistrian / David F. Driscoll

74 Biology of Obesity Jeffrey S. Flier / Eleftheria Maratos-Flier

75 Evaluation and Management of Obesity Robert F. Kushner

76 Eating Disorders B. Timothy Walsh

Part 6

Oncology and Hema tology

Section 1

Neoplastic Disorders

77 Approach to the Patient with Cancer Dan L. Longo

78 Prevention and Early Detection of Cancer Otis W. Brawley / Barnett S. Kramer

79 Cancer Genetics Pat J. Morin / Jeffrey M. Trent / Francis S. Collins / Bert Vogelstein

80 Cancer Cell Biology and Angiogenesis Robert G. Fenton / Dan L. Longo

81 Principles of Cancer Treatment Edward A. Sausville / Dan L. Longo

82 Infections in Patients with Cancer Robert Finberg

83 Cancer of the Skin Arthur J. Sober / Hensin Tsao / Carl V. Washington

84 Head and Neck Cancer Everett E. Vokes

85 Neoplasms of the Lung John D. Minna / Joan H. Schiller

86 Breast Cancer Marc E. Lippman

87 Gastrointestinal Tract Center Robert J. Mayer

88 Tumors of the Liver and Biliary Tree Brian I. Carr

89 Pancreatic Cancer Yu Jo Chua / David Cunningham

90 Bladder and Renal Cell Carcinomas Howard I. Scher / Robert J. Motzer

91 Benign and Malignant Diseases of the Prostate Howard I. Scher

92 Testicular Cancer Robert J. Motzer / George J. Bosl

93 Gynecologic Malignancies Robert C. Young

94 Soft Tissue and Bone Sarcomas and Bone Metastases Shreyaskumar R. Patel / Robert S. Benjamin

95 Carcinoma of Unknown Primary Gauri R. Varadhachary /James L. Abbruzzese

96 Paraneoplastic Syndromes: Endocrinologic/Hematologic J. Larry Jameson / Bruce E. Johnson

97 Paraneoplastic Neurologic Syndromes Joseph Dalmau / Myrna R. Rosenfeld

e12 Thymoma Dan L. Longo

e13 Late Consequences of Cancer and Its Treatment Michael C. Perry / Dan L. Longo

Section 2

Hematopoietic Disorders

98 Iron Deficiency and Other Hypoproliferative Anemias John W. Adamson

99 Disorders of Hemoglobin Edward J. Benz

100 Megaloblastic Anemia A. Victor Hoffbrand

101 Hemolytic Anemias and Anemias due to Acute Blood Loss Lucio Luzzatto

102 Aplastic Anemia, Myelodysplasia, a nd Related Bone Marrow Failure Syndromes Neal S. Young

103 Polycythemia Vera and Other Myeloproliferative Diseases Jerry L. Spivak

104 Acute and Chronic Myeloid Leukemia Meir Wetzler /John C. Byrd / Clara D. Bloomfield

105 Malignancies of Lymphoid Cells Dan L. Longo

106 Plasma Cell Disorders Nikhil C. Munshi / Dan L. Longo / Kenneth C. Anderson

107 Transfusion Biology and Therapy Jeffery S. Dzieczkowski / Kenneth C. Anderson

108 Hematopoietic Cell Transplantation Frederick R. Applebaum

Section 3

Disorders of Hemostasis

109 Disorders of Platelets and Vessel Wall Barbara A. Konkle

110 Coagulation Disorders Valder Arruda / Katherine High

111 Thrombosis Venous F.R. Rosendaal / H.R. Büller

112 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs Jeffery L. Weitz

Part 7

Infectious Diseases

Section 1

Basic Considerations in Infectious Diseases

113 Introduction to Infectious Diseases: Host-Pathogen Interactions Lawrence C. Madoff / Dennis L. Kasper

114 Molecular Mechanisms of Microbial Pathogenesis Gerald B. Pier

115 Approach to the Acutely Ill Infected Febrile Patient Tamar F. Barlam / Dennis L. Kasper

116 Immunization Principles and Vaccine Use Gerald T. Keusch / Kenneth J. Bart / Mark Miller

117 Health Advice for International Travel J.S. Keystone / P.E. Kozarsky

e14 Laboratory Diagnosis of Infectious Diseases Alexander J. McAdam / Andrew B. Onderdonk

Section 2

Clinical Syndromes: Community-Acquired Infections

118 Infective Endocarditis Adolf W. Karchmer

119 Infections of the Skin, Muscle, and Soft Tissues Dennis L. Stevens

120 Osteomyelitis Jeffrey Parsonnet

121 Intraabdominal Infections and Abscesses Miriam J. Baron / Dennis L. Kasper

122 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning Joan R. Butterton / Stephen B. Calderwood

123 Clostridium difficile-Associated Disease, Includ ing Pseudomembranous Colitis Dale N. Gerding / Stuart Johnson

124 Sexually Transmitted Infections: Overview and Clinical Approach King K. Holmes

e15 Infectious Complications of Bites and Burns Lawrence C. Madoff / Florencia Pereyra

Section 3

Clinical Syndromes: Nosocomial Infections

125 Health Care-Associated Infections Robert A. Weinstein

126 Infections in Transplant Recipients Robert Finberg /Joyce Fingeroth

Section 4

Approach to Therapy for Bacterial Diseases

127 Treatment and Prophylaxis of Bacterial Infections Gordon L. Archer / Ronald E. Polk

Section 5

Diseases Caused by Gram-Positive Bacteria

128 Pneumococcal Infections Daniel M. Musher

129 Staphylococcal Infections Franklin D. Lowy

130 Strepococcal and Enterococcal Infections Michael R. Wessels

131 Diphtheria and Other Infections Caused by Corynebacteria and Related Species William R. Bishai / Jack R. Murphy

132 Infections Caused by Listeria monocytogenes Elizabeth L. Hohmann / Daniel A. Portnoy

133 Tetanus Elias Abrutyn

134 Botulism Elias Abrutyn

135 Gas Gangrene and Other Clostridial Infections Dennis L. Kasper /Lawrence C. Madoff

Section 6

Diseases Caused by Gram-Negative Bacteria

136 Meningococcal Infections Lee M. Wetzler

137 Gonococcal Infections Sanjay Ram / Peter A. Rice

138 Moraxella Infections Daniel M. Musher

139 Haemophilus Infections Timothy F. Murphy

140 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria Tamar F. Barlam / Dennis L. Kasper

141 Legionella Infection Miguel Sabria / Victor L. Yu

142 Pertussis and Other Bordetella Infections Scott A. Halperin

143 Diseases Caused by Gram-Negative Enteric Bacilli Thomas A. Russo / James R. Johnson

144 Helicobacter Pylori Infections John C. Atherton / Martin J. Blaser

145 Infections Due to Pseudomonas Species and Related Organisms Reuben Ramphal

146 Salmonellosis David A. Pegues / Samuel I. Miller

147 Shingellosis Philippe Sansonetti / Jean Bergounioux

148 Infections Due to Campylobacter and Related Species Martin J. Blaser

149 Cholera and Other Vibrioses Matthew K. Waldor / Gerald T. Keusch

150 Brucellosis Michael J. Corbel / Nicholas J. Beeching

151 Tularemia Richard F. Jacobs / Gordon E. Schutze

152 Plague and Other Yersnia Infections David T. Dennis / Grant L. Campbell

153 Bartonella Infections, Including Cat-Scratch Disease David H. Spach / Emily Darby

154 Donovanosis Gavin Hart

Section 7

Miscellaneous Bacterial Infections

155 Nocardiosis Gregory A. Filice

156 Actinomycosis Thomas A. Russo

157 Infections Due to Mixed Anaerobic Organisms Dennis L. Kasper / Ronit Cohen-Poradosu

Section 8

Mycobacterial Diseases

158 Tuberculosis Mario C. Raviglione / Richard J. O’Brien

159 Leprosy (Hansen’s Disease) Robert H. Gelber

160 Nontuberculous Mycobacteria C. Fordham von Reyn

161 Antimycobacterial Agents Richard J. Wallace / David E. Griffith

Section 9 Spirochetal Disease

162 Syphilis Sheila A. Lukehart

163 Endemic Treponematoses Sheila A. Lukehart

164 Leptospirosis Peter Speelman / Rudy Harkskeerl

165 Relapsing Fever David T. Dennis

166 Lyme Borreliosis Allen C. Steere

Section 10 Diseases Caused by Rickettsia, Mycoplasma, and Chlamydia

167 Rickettsial Diseases David H. Walker / J. Stephen Dumler / Thomas Marrie

168 Infections Due to Mycoplasmas William M. McCormack

169 Chlamydial Infections Walter E. Stamm

Section 11

Viral Diseases: General Considerations

170 Medical Virology Fred Wang /Elliott Kieff

171 Antiviral Chemotherapy, Excluding Antiretroviral Drugs Lindsey R. Baden / Raphael Dolin

Section 12

Infections Due to DNA Viruses

172 Herpes Simplex Viruses Lawrence Corey

73 Va ricella-Zoster Virus Infections Richard J. Whitley

174 Epstein-Barr Virus Infections, Including Infectious Mononucleosis Jeffery I. Cohen

175 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8 Martin S. Hirsch

176 Molluscum Contagiosum, Monkeypox and Other Poxviruses Excluding Smallpox Virus Fred Wang

177 Parvovirus Infections Kevin E. Brown

178 Human Papillomavirus Infections Richard C. Reichman

Section 13

Infections Due to DNA and RNA Respiratory Viruses

179 Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome (SARS) Raphael Dolin

180 Influenza Raphael Dolin

Section 14

Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses

181 The Human Retroviruses Dan L. Longo /Anthony S. Fauci

182 Human Immunodeficiency Virus Disease: AIDS and Related Disorders Anthony S. Fauci / H. Clifford Lane

Section 15

Infections Due to RNA Viruses

183 Viral Gastroenteritis Umesh D. Parashar / Roger I. Glass

184 Enterovirus and Reoviruses Infections Jeffery I. Cohen

185 Measles (Rubeola) Anne Gershon

186 Rubella (German Measles) Anne Gershon

187 Mumps Anne Gershon

188 Rabies and Other Rhabdovirus Infections Alan C. Jackson / Eric C. Johannsen

189 Infections Caused by Arthropod and Rodent-Borne Viruses Clarence J. Peters

190 Ebola and Marburg Viruses Clarence J. Peters

Section 16

Fungal and Algal Infections

191 Diagnosis and Treatment of Fungal Infections John E. Edwards

192 Histoplasmosis Chadi A. Hage / L. Joseph Wheat

193 Coccidioidomycosis Neil M. Ampel

194 Blastomycosis Stanley W. Chapman

195 Cryptococcosis Arturo Casadevall

196 Candidiasois John E. Edwards

197 Aspergillosis David W. Denning

198 Mucormycosis Alan M. Sugar

199 Miscellaneous Mycoses and Algal Infections Stanley W. Chapman / Donna C. Sullivan

200 Pneumocystis Infection A. Geroge Smulian /Peter D. Walzer

Section 17

Protozoal and Helminthic Infections: General Considerations

e16 Laboratory Diagnosis of Parasitic Infections Sharon L. Reed / Charles E. Davis

201 Agents Used to Treat Parasitic Infections Thomas A. Moore

e17 Pharmacology of Agents Used to Treat Parasitic Infections Thomas A. Moore

Section 18

Protozoal Infections

202 Ambiasis and Infection with Free-Living Amebas Sharon L. Reed

203 Malaria Nicholas J. White / Joel G. Breman

204 Babesiosis Jeffery Gelfand

e18 Atlas of Blood Smears of Malaria and Babesiosis Nicholas J. White / Joel G. Breman

205 Leishmaniasis Barbara L. Herwaldt

206 Trypanosomiasis Louis V. Kirchhoff

207 Toxoplasma Infections Lloyd H. Kasper

208 Protozoal Intestinal Infections and Trichomoniasis Peter F. Weller

Section 19

Helminthic Infections

209 Trichinella and Other Tissue Nematodes Peter F. Weller

210 Intestinal Nematodes Peter F. Weller /Thomas B. Nutman

211 Filarial and Related Infections Peter F. Weller / Thomas B. Nutman

212 Schistosomiasis and Other Trematode Infections Adel A.F. Mahmoud

213 Cestodes A. Clinton White, Jr. / Peter F. Weller

Part 8

Bioterrorism and Clinical Medicine

214 Microbioterrorism H. Clifford Lane / Anthony S. Fauci

215 Chemical Bioterrorism Charles G. Hurst / Jonathan Newmark / James A. Romano

216 Radiation Bioterrorism Zelig A. Tochner / Eli Glatstein

Part 9

Disorders of Cardiovascular System

Section 1

Introduction to Cardiovascular Disorders

217 Basic Biology of the Cardiovascular System Joseph Loscalzo / Peter Libby / Eugene Braunwald

218 Epidemiology of Cardiovascular Disease Thomas A. Gaziano / J. Michael Gaziano

219 Approach to the Patient with Possible Cardiovascular Disease Eugene Braunwald

Section 2

Diagnosis of Cardiovascular Disorders

220 Physical Examination of the Cardiovascular System Robert A. O’Rourke /Eugene Braunwald

221 Electrocardiography Ary L. Goldberger

e19 Atlas of Electrocardiography Ary L. Goldberger

222 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging Rick Nishimura / Raymond J. Gibbons / James F. Glockner /A. Jamil Tajik

e20 Atlas of Noninvasive Cardiac Imaging Rick Nishimura

223 Diagnostic Cardiac Catheterization and Angiography Donald S. Baim

Section 3

Disorders of Rhythm

224 Principles of Electrophysiology Gordon F. Tomaselli

225 The Bradyarrhythmias Gordon F. Tomaselli

226 The Tachyarrhythmias Francis Marchlinksi

e21 Atlas of Cardiac Arrhythmias Ary L. Goldberger

Section 4

Disorders of the Heart

227 Heart Failure and Cor Pulmonale Douglas L. Mann

228 Cardiac Transplantation and Prolonged Assisted Circulation Sharon A. Hunt

229 Congenital Heart Disease in the Adult John S. Child

230 Valvular Heart Disease Patrick O’Gara / Eugene Braunwald

231 Cardiomyopathy and Myocarditis Joshua Wynne / Eugene Braunwald

232 Pericardial Disease Eugene Braunwald

233 Tumors and Trauma of the Heart Eric H. Awtry / Wilson S. Colucci

234 Cardiac Manifestations of Systemic Disease Eric H. Awtry / Wilson S. Colucci

Section 5

Vascular Disease

235 The Pathogenesis, Prevention, and Treatment of Atherosclerosis Peter Libby

e22 Atlas of Atherosclerosis Peter Libby

236 The Metabolic Syndrome Robert H. Eckel

237 Ischemic Heart Disease Elliott M. Antman / Andrew P. Selwyn/ Eugene Braunwald / Joseph Loscalzo

238 Unstable Angina and Non-ST-Elevation Myocardial Infarction Christopher P. Cannon / Eugene Braunwald

239 ST-Segment Elevation Myocardial Infarction Elliott M. Antman / Eugene Braunwald

240 Percutaneous Coronary Intervention Donald S. Baim

e23 Atlas of Percutaneous Revascularization Donald S. Baim

241 Hypertensive Vascular Disease Ted A. Kotchen

242 Diseases of the Aorta Mark A. Creager / Joseph Loscalzo

243 Vascular Diseases of the Extremities Mark A. Creager / Joseph Loscalzo

244 Pulmonary Hypertension Stuart Rich

Part 10

Disorders of the Respiratory System

Section 1

Diagnosis of Respiratory Disorders

245 Approach to the Patient with Disease of the Respiratory System David A. Lipson / Steven E. Weinberger

246 Disturbances of Respiratory Function Steven E. Weinberger /Ilene M. Rosen

247 Diagnostic Procedures in Respiratory Diseases Scott Manaker / Steven E. Weinberger

e24 Atlas of Chest Imaging Patricia Kritek / John J. Reilly, Jr.

Section 2

Diseases of the Respiratory System

248 Asthma Peter J. Barnes

249 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia Joel N. Kline / Gary W. Hunninghake

250 Environmental Lung Disease Frank E. Speizer / John R. Balmes

251 Pneumonia Lionel A. Mandell / Richard Wunderink

252 Bronchiectasis and Lung Abscess Gregory Tino / Steven E. Weinberger

253 Cystic Fibrosis Richard C. Boucher

254 Chronic Obstructive Pulmonary Disease John J. Reilly, Jr. / Edwin K. Silverman / Steven D. Shapiro

255 Interstitial Lung Diseases Talmadge E. King, Jr.

256 Deep Venous Thrombosis and Pulmonary Thromboembolism Samuel Z. Goldhaber

257 Disorders of the Pleura and Mediastinum Richard W. Light

258 Disorders of Ventilation Eliot A. Phillipson

259 Sleep Apnea Neil J. Douglas

260 Lung Transplantation Elbert P. Trulock

Part 11

Critical Care Medicine

Section 1

Respiratory Critical Care

261 Principles of Critical Care Medicine John P. Kress / Jesse B. Hall

262 Acute Respiratory Distress Syndrome Bruce D. Levy / Steve D. Shapiro

263 Mechanical Ventilatory Support Edward P. Ingenito

Se ction 2

Shock and Cardiac Arrest

264 Approach to the Patient with Shock Ronald V. Maier

265 Severe Sepsis and Septic Shock Robert S. Munford

266 Cardiogenic Shock and Pulmonary Edema Judith S. Hochman / David H. Ingbar

267 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death Robert J. Myerberg / Agustin Castellanos

Section 3

Neurologic Critical Care

268 Coma Allan H. Ropper

269 Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy and Subarachnoid Hemorrhage J. Claude Hemphill / Wade S. Smith

Section 4

Oncologic Emergencies

270 Oncologic Emergencies Rasim Gucalp / Janice Dutcher

Part 12

Disorders of the Kidney and Urinary Tract

271 Cellular and Molecular Biology of the Kidney Alfred L. George / Eric G. Neilson

272 Adaptation of the Kidney to Renal Injury Raymond C. Harris / Eric G. Neilson

273 Acute Renal Failure Kathleen D. Liu / Glenn M. Chertow

274 Chronic Kidney Disease Joanne M. Bargman / Karl Skorecki

275 Dialysis in the Treatment of Renal Failure Kathleen D. Liu / Glenn M. Chertow

276 Transplantation in the Treatment of Renal Failure Charles B. Carpenter / Edgar L. Milford / Mohamed H. Sayegh

277 Glomerular Diseases Julia B. Lewis / Eric G. Neilson

278 Polycystic Kidney Disease and Other Inherited Tubular Disorders David J. Salant / Parul S. Patel

279 Tubulointerstitial Diseases of the Kidney Alan S. L. Yu / Barry M. Brenner

280 Vascular Injury to the Kidney Kamal F. Badr / Barry M. Brenner

281 Nephrolithiasis John R. Asplin / Fredric L. Coe / Murray J. Favus

282 Urinary Tract Infections, Pyelonephritis, and Prostatitis Walter E. Stamm

283 Urinary Tract Obstruction Julian L. Seifter / Barry M. Brenner

Part 13

Disorders of the Gastrointestinal System

Section 1

Disorders of the Alimentary Tract

284 Approach to the Patient with Gastrointestinal Dis ease William L. Hasler / Chung Owyang

285 Gastrointestinal Endoscopy Louis Michel Wong Kee Song / Mark Topazian

e25 Video Atlas of Gastrointestinal Endoscopy Mark Topazian

286 Diseases of the Esophagus Raj. K. Goyal

287 Peptic Ulcer Disease and Related Disorders John Del Valle

288 Disorders of Absorption Henry J. Binder

289 Inflammatory Bowel Disease Sonia Friedman / Richard S. Blumberg

290 Irritable Bowel Syndrome Chung Owyang

291 Diverticular Disease and Common Anorectal Disorders Susan L. Gearhart

292 Mesenteric Vascular Insufficiency Susan L. Gearhart

293 Acute Intestinal Obstruction Susan L. Gearhart / William Silen

294 Acute Appendicitis and Peritonitis Susan L. Gearhart / William Silen

Section 2

Liver and Biliary Tract Disease

295 Approach to the Patient with Liver Disease Marc Ghany /Jay H. Hoofnagle

296 Evaluation of Liver Function Daniel S. Pratt / Marshall M. Kaplan

297 The Hyperbilirubinemias Allan W. Wolkoff

298 Acute Viral Hepatitis Jules L. Dienstag

299 Toxic and Drug-Induced Hepatitis Jules L. Dienstag

300 Chronic Hepatitis Jules L. Dienstag

301 Alcoholic Liver Disease Mark E. Malliard / Michael F. Sorrell

302 Cirrhosis and Its Complications Bruce R. Bacon

e26 Atlas of Liver Biopsies Jules L. Dienstag / Atul K. Bhau

303 Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver Bruce R. Bacon

304 Liver Transplantation Jules L. Dienstag /Raymond T. Chung

305 Diseases of the Gallbladder and Bile Ducts Norton J. Greenberger / Gustav Paumgartner

Section 3

Disorders of the Pancreas

306 Approach to the Patient with Pancreatic Disease Phillip P. Toskes / Norton J. Greenberger

307 Acute and Chronic Pancreatitis Norton J. Greenberger / Phillip P. Toskes

Part 14

Disorders of the Immune System, Connective Tissue, and Joints

Section 1

The Immune System in Health and Disease

308 Introduction to the Immune System Barton F. Haynes / Kelly A. Soderberg / Anthony S. Fauci

309 The Major Histocompatability Complex Gerald T. Nepom

310 Primary Immune Deficiency Diseases Max D. Cooper / Harry W. Schroeder, Jr.

e27 Primary Immunodeficiencies Associated with or Secondary to Other Diseases Max D. Cooper

Section 2

Disorders of Immune-Mediated Injury

311 Allergies, Anaphylaxis, and Systemic Mastocytosis K. Frank Austen

312 Autoimmunity and Autoimmune Diseases Peter E. Lipsky / Betty Diamond

313 Systemic Lupus Erythematosus Bevra Hannahs Hahn

314 Rheumatoid Arthritis Peter E. Lipsky

315 Acute Rheumatoid Fever Jonathan R. Carapetis

316 Systemic Sclerosis (Scleroderma) and Related Disorders John Varga

317 Sjögren’s Syndrome Haralampos M. Moutsopoulos

318 The Spondyloarthritides Joel D. Taurog

319 The Vasculitis Syndromes Carol A. Langford / Anthony S. Fauci

e28 Atlas of Clinical Imaging of the Vasculitic Diseases Carol A. Langford / Anthony S. Fauci

320 Behçet’s Syndrome Haralampos M. Moutsopoulos

321 Relapsing Polychondritis Carol A. Langford /Bruce C. Gilliland

322 Sarcoidosis Robert P. Baughman /Elyse E. Lower

323 Familial Mediterranean Fever and Other Hereditary Recurrent Fevers Daniel L. Kastner

324 Amyloidosis David C. Seldin / Martha Skinner

Section 3

Disorders of the Joints and Adjacent Tissues

325 Approach to Articular and Musculoskeletal Disorders John J. Cush / Peter E. Lipsky

326 Osteoarthritis David T. Felson

327 Gout and Other Crystal Arthropathies H. Ralph Schumacher / Lan X. Chen

328 Infectious Arthritis Lawrence C. Madoff

329 Fibromyalgia Carol A. Langford /Bruce C. Gilliland

330 Arthritis Associated with Systemic Disease and Other Arthritides Carol A. Langford / Bruce C. Gilliland

331 Periarticular Disorders of th e Extremities Carol A. Langford / Bruce C. Gilliland

Part 15

Endocrinology and Metabolism

Section 1

Endocrinology

332 Principles of Endocrinology J. Larry Jameson

333 Disorders of the Anterior Pituitary and Hypothalamus Shlomo Melmed / J. Larry Jameson

334 Disorders of the Neurohypophysis Gary L. Robertson

335 Disorders of the Thyroid Gland J. Larry Jameson / Anthony P. Weetman

336 Disorders of the Adrenal Cortex Gordon H. Williams / Robert G. Dluhy

337 Pheochromocytoma Hartmut P.H. Neumann

338 Diabetes Mellitus Alvin C. Powers

339 Hypoglycemia Phillip E. Cryer

340 Disorders of the Testes and the Male Reproductive System Shalender Bhasin / J. Larry Jameson

341 Disorders of the Ovary and Female Reproductive Tract Janet E. Hall

342 The Menopause Transition and Postmenopausal Hormone Therapy JoAnn E. Manson /Shari S. Bassuk

343 Disorders of Sex Development John C. Achermann / J. Larry Jameson

344 Endocrine Tumors of the Gastrointestinal Tract and Pancreas Robert T. Jensen

345 Disorders Affecting Multiple Endocrine Neoplasia Syndromes Camillo Jimenez / Robert Gagel

Section 2

Disorders of Bone and Mineral Metabolism

346 Bone and Mineral Metabolism in Health and Disease F. Richard Bringhurst / Marie B. Demay / Stephen M. Krane / Henry M. Kronenberg

347 Diseases of the Parathyroid Gland and Other Hyper- and Hypocalcemia Disorders John T. Potts, Jr.

348 Osteoporosis Robert Lindsay / Felicia Cosman

349 Paget Disease and Other Dysplasias of Bone Murray J. Favus /Tamara J. Vokes

Section 3

Disorders of Intermediary Metabolism

350 Disorders of Lipoprotein Metabolism Daniel J. Rader / Helen H. Hobbs

351 Hemochromatosis Lawrie W. Powell

352 The Porphyrias Robert J. Desnik / Kenneth H. Astrin

353 Disorders of Purine and Pyrimidine Metabolism Robert L. Wortmann

354 Wilson Disease George J. Brewer

355 Lysosomal Storage Disease Robert J. Hopkin / Gregory A. Grabowski

356 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism Yuan-Tsong Chen

357 Heritable Disorders of Connective Tissue Darwin J. Prockop / Malwina Czarny-Ratajczak

358 Inherited Disoders of Amino Acid Metabolism in Adults Nicola Longo

359 Inherited Defects of Membrane Transport Nicola Longo

e29 Atlas of Clinical Manifestations of Metabolic Diseases J. Larry Jameson

Part 16

Neurologic Disorders

Section 1

Diagnosis of Neurologic Disorders

360 Mechanisms of Neurologic Disorders Stephen Hauser / M. Flint Beal

361 Approach to the Patient with Neurologic Disease Daniel H. Lowenstein / Joseph B. Martin / Stephen L. Hauser

362 Neuroimaging in Neurologic Disorders William P. Dillon

e30 Atlas of Neuroimaging Andre Furtado / William P. Dillon

e31 Electrodiagnostic Studies of Nervous System Disorders: EEG and EMG Michael J. Aminoff

e32 Technique of Lumbar Puncture Elizabeth Robbins / Stephen L. Hauser

Section 2

Diseases of the Central Nervous System

363 Seizures and Epilepsy Daniel H. Lowenstein

364 Cerebrovascular Diseases Wade S. Smith / Joey English / S. Claiborne Johnston

365 Dementia Thomas D. Bird / Bruce L. Miller

366 Parkinson’s Disease and Other Extrapyramidal Disorders Mahlon R. DeLong / Jorge L. Juncos

367 Hyperkinetic Movement Disorders C. Warren Olanow

368 Ataxic Disorders Roger N. Rosenberg

369 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases Robert H. Brown, Jr.

370 Disorders of the Autonomic Nervous System Phillip A. Low / John W. Engstrom

371 Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders M. Flint Beal / Stephen L. Hauser

372 Diseases of the Spinal Cord Stephen L. Hauser / Allan H. Ropper

373 Concussion and Other Head Injuries Allan H. Ropper

374 Primary and Metastatic Tumors of the Nervous System Stephen M. Sagar / Mark A. Israel

375 Multiple Sclerosis and Other Demyelinating Diseases Stephen L. Hauser / Douglas S. Goodin

376 Meningitis, Encephalitis, Brain Abscess,and Empyema Karen L. Roos / Kenneth L. Tyler

377 Chronic and Recurrent Meningitis Walter J. Koroshetz / Morton N. Swartz

378 Prion Diseases Stanley B. Prusiner / Bruce L. Miller

Section 3

Nerve and Muscle Disorders

379 Peripheral Neuropathy Vinay Chaudhry

380 Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies Steven L. Hauser / Arthur K. Asbury

381 Mysathenia Gravis and Other Diseases of the Neuromuscular Junction Daniel B. Drachman

382 An Approach to Muscular Dystrophy and Other Muscle Diseases Robert H. Brown, Jr. / Anthony A. Amato / Jerry R. Mendell

383 Polymyositis, Dermatomyositis, and Inclusion Body Myositis Marinos C. Dalakas

e33 Special Issues in Inpatient Neurologic Consultation S. Andrew Josephson / Martin A. Samuels

Section 4

Chronic Fatigue Syndrome

384 Chronic Fatigue Syndrome Stephen E. Straus

Section 5

Psychiatric Disorders

385 Biology of Psychiatric Disorders Steve Hyman / Eric Kandel

386 Mental Disoders Victor I. Reus

Section 6

Alcoholism and Drug Dependency

387 Alcohol and Alcoholism Marc A. Schuckit

388 Opioid Drug Abuse and Dependence Mark A. Schuckit

389 Cocaine and Other Commonly Abused Drugs Jack H. Medelson / Nancy K. Mello

390 Nicotine Addiction David M. Burns

Part 17

Poisoning, Drug Overdose, and Envenomation

e34 Heavy Metal Poisoning Howard Hu

e35 Poisoning and Drug Overdosage Christopher H. Linden / Michael J. Burns / Mark B. Mycyk

391 Disorders Caused by Reptile Bites and Marine Animal Exposures Paul Auerbach / Robert Norris

e36 Ectoparasite Infestations and Arthropod Bites and Stings Richard J. Pollack / James H. Maguire

International e Chapters

e37 Pulmonary Biomarkers in COPD Peter J. Barnes

e38 Chagas’ Disease: Recent Advances in Diagnosis and Management Andrei C. Sposito / Jose A.F. Ramires

Summaries of Chapters e1 to e36

Appendix

Laboratory Values of Clinical Importance Alexander Kratz / Michael A. Pesce / Daniel J. Fink

Index