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Table of Contents
Preface
Contributors
Part I Cellular and Molecular Basis for Heart Failure
The Genetics of Dilated and Hypertrophic Cardiomyopathies
Calum A. MacRae
Molecular Signaling Networks Underlying Cardiac Hypertrophy and Failure
Jeffery D. Molkentin
Thomas Force
Mechanisms of Cell Death in Heart Failure
Jagat Narula
Anthony Rosenzweig
Excitation-Contraction Coupling Mechanisms in Heart Failure
Federica del Monte
Roger J. Hajjar
ß-Adrenergic Signaling in Heart Failure
Stefan Engelhardt
Part II Pathophysiology of Heart Failure
Ventricular Remodeling and Secondary Valvular Dysfunction in Heart Failure Progression
Judy Hung
Khurram Shahzad
Ronen Beeri
Robert A. Levine
Neurohormonal and Cytokine Activation in Heart Failure
Dennis M. McNamara
Cardiomyopathies in the Adult (Dilated, Hypertrophic, and Restrictive)
Richard Rodeheffer
Heart Failure with Normal Systolic Function
Johan Sundstrom
Ramachandran S. Vasan
Part III Clinical Heart Failure: Diagnosis and Treatment
The Clinical Syndrome of Heart Failure
Thomas DiSalvo
Clinical Profiles and Prognosis in Heart Failure
Lynne Warner Stevenson
Paul Zei
Conventional Therapy of Chronic Heart Failure: Diuretics, Angiotensin-Converting Enzyme Inhibitors, and Digoxin
G. William Dec
Conventional Therapy of Chronic Heart Failure: Beta-Adrenergic Blockers
G. William Dec
Angiotensin Receptor Blockers for Heart Failure
John G. F. Cleland
Nikolay Nikitin
Justin Ghosh
Alison P. Coletta
Anwar Memon
Andrew Clark
Role of Mineralocorticoid Antagonists in Patients with Heart Failure
Bertram Pitt
Sanjay Rajagopalan
New Pharmacologic Therapies in Heart Failure: Immunotherapy, Endothelin-1 Antagonists, Brain Natriuretic Peptides, and Neurohormonal Interventions
Cynthia K. Wallace
Kumudha Ramasubbu
Guillermo Torre-Amione
Treatment of Diastolic Heart Failure
William H. Gaasch
Theo E. Meyer
Cardiac Resynchronization Therapy
William T. Abraham
Management of Atrial and Ventricular Arrhythmias in Heart Failure
Usha Tedrow
William G. Stevenson
Heart Failure in Special Populations
Clyde W. Yancy
Practice Guidelines for Heart Failure Management
Thomas H. Lee
Part IV Surgical Options for Heart Failure
Coronary Revascularization, Mitral Valve Repair, Left Ventricular Remodeling, Procedures and Devices
Patrick M. McCarthy
Katherine J. Hoercher
Richard Lee
Long Term Mechanical Circulatory Support and Cardiac Transplantation
Peter C. Kouretas
Susan Moffatt-Bruce
Robert C. Robbins
Part V Molecular Therapies
Targeted Gene Transfer in Heart Failure
Roger J. Hajjar
Anthony Rosenzweig
Cellular Transplantation
Philippe Menasche
Index
