The Role of Inflammatory Mediators in the Failing Heart

Edited by: Douglas L. Mann

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The Role of Inflammatory Mediators in the Failing Heart

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Product Information:
ISBN-13: 9780792373810
ISBN-10: 0792373812
Publisher: Springer
Format: Hardback, 120 pages
Pub Date: 08/2001
Edition Number: 1

Synopsis

Although clinicians have recognized the importance of inflammatory mediators in the pathogenesis of heart disease for well over 200 years, it has taken nearly as many years for clinicians and scientists to focus on the basic biological mechanisms by which inflammatory mediators contribute to the pathogenesis of cardiac disease states. Over the past decade there has been increasing interest in the potential role that inflammatory mediators, play in a variety of cardiac disease states, including chronic heart failure.
The Role of Inflammatory Mediators in the Failing Heart provides a state-of-the-art review on inflammatory mediators and the failing heart. This book will serve both as a useful introduction to the field, as well as an update for those interested in the role of inflammatory mediators and the failing heart.

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Additional Description

Edited by
Douglas L. Mann, M.D.
Director, Winters Center for Heart Failure Research, Gordon
Cain Chair and Professor of Medicine, Baylor College of
Medicine, Houston, Texas
TABLE OF CONTENTS
1. Introduction/Brief Overview 1
Douglas L. Mann
2. Recent Insights into the Role of Tumor Necrosis Factor in
the Failing Heart 3
Douglas L. Mann
3. The Role of Interleukin-1 in the Failing Heart 13
Carlin S. Long
4. The Role of Interleukin-6 in the Failing Heart 27
Kai C. Wollert, Helmut Drexler
5. The Role of Nitric Oxide in the Failing Heart 35
Walter J. Paulus
6. Interactions Between Cytokines and Neurohormonal
Systems in the Failing Heart 49
Hong Kan, Mitchell S. Finkel
7. Experimental Heart Failures Models of Cytokine
Overexpression 59
Charles F. McTiernan, Toshi Kadokami, Yun You
Li, Arthur M. Feldman
8. Immunomodulation of Cytokines in Experimental Models
of Heart Failure 69
Akira Matsumori, Shigetake Sasayama
9. The Effect of Cytokines on Cardiac Allograft Function:
Tumor Necrosis Factor-a: a Mediator of Chronic Injury 77
Alex Perez-Verdia, Sonny J. Stetson, Susan McRee,
Wojciech Mazur, Michael M. Koerner, Guillermo
Torre-Amione
10. The Role of Anti-Cytokine Therapy in the Failing Heart
83
Anita Deswal, Arunima Misra, Biykem Bozkurt
11. The Syndrome of Cardiac Cachexia 93
Stefan D. Anker, Rakesh Sharma
Index 105