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Vascular Disease and Injury: Preclinical Research

Daniel I. Simon


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Product Information:
ISBN-13: 9780896037533
ISBN-10: 0896037533
Publisher: HUMANA PRESS
Format: Hardcover, 338 pages
Pub Date: 01/2000
Edition Number: 1




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CONTENTS

Foreword by Victor J. Dzau v
Preface I vii
Contributors xiii
Color Plates xvii

PART I ACUTE MECHANICAL INJURY AND
VASCULAR REPAIR
1 Mechanical Injury in Normal and Atherosclerotic
Rabbit Iliac Arteries 3
Frederick G.P. Welt, Elazer R. Edelman,
and Campbell Rogers
2 The Porcine Model of Coronary Restenosis 19
Robert S. Schwartz, Birgit Kantor, and David R.
Holmes Jr.
3 Atherosclerotic Porcine Coronary Stent Model:
Technical Methods for Preclinical Studies 43
Andrew J. Carter
4 Nonhuman Primate Models of Arterial Injury and
Repair 53
Mark Nedelman, Christopher Horvath, and Campbell
Rogers
5 Experimental Models of Arteriovenous Grafting 61
Afshin Ehsan, Michael J. Mann, and Victor J. Dzau
6 Wire Denudation and Ligation Models of the
Mouse Carotid Artery 79
Volkhard Lindner
7 Endothelial Denudation and Arterial Dilation in the
Mouse 87
Zhiping Chen, Campbell Rogers, and Daniel I.
Simon
8 Vascular Photochemical Injury in the Mouse 95
Daniel T. Eitzman and Randal J. Westrick
9 Mouse Model of Transluminal Femoral Artery
Injury 103
Ernane D. Reis, Susan S. Smyth, and Barry S. Colter

PART II MODELS OF ARTERIAL THROMBOSIS

10 A Murine Model of Arterial Injury and
Thrombosis 117
William P. Fay, Andrew C. Parker, and Yanhong
Zhu
11 Folts Cyclic Flow Animal Model for Studying In
Vivo Platelet Activity and Platelet Interactions
with Damaged Arterial Walls 127
John D. Folts

PART III CHRONIC ATHEROSCLEROTIC MODELS
12 Mouse Models of Atherosclerosis 149
Wulf Palinski, Claudio Napoli, and Peter D. Reaven
13 Rabbit Models of Atherosclerosis 175
Masanori Aikawa, Yoshihiro Fukumoto, Elena
Rabkin, and Peter Libby
14 Atherosclerosis in Nonhuman Primates 193
David Kritchevsky and Robert J. Nicolosi

PART IV VASCULAR DISEASE IN TRANSPLANTED
VESSELS
15 Murine Carotid Loop Model of Transplant
Vascular Disease 207
Victor Chengwei Shi and Jennifer L. Hoover
16 Murine Heterotopic Model of Transplant
Arteriopathy 215
Richard N. Mitchell
17 Hyperacute Vascular Rejection: Lessons from
Pig-to-Primate Xenotransplantation 231
Raymond H. Chen and David H. Adams

PART V VASCULAR DISEASE IN MODELS OF
ARTERIAL HYPERTENSION
18 Methods for Examining Cerebrovascular Disease
in Experimental Models of Hypertension 247
Gary L. Baumbach
19 Monocrotaline-Induced Pulmonary
Hypertension in Rats 261
Marlene Rabinovitch
20 Chronic Pulmonary Hypertension in the Hypoxic
Rat and in the Sheep Following Continuous Air
Embolization 281
Barbara Meyrick and Elena Tchekneva

PART VI ANIMAL CARE AND TISSUE
PROCESSING
21 Veterinary Issues and Anesthesia Options 303
Robert P. Marini
22 Histological and Immunohistochemical Methods
for Vascular Animal Model Studies 325
Philip Seifert, Campbell Rogers, and Elazer R.
Edelman
Index 339

CONTRIBUTORS

DAVID H. ADAMS, MD Department of Surgery, Brigham
and Women's Hospital, Harvard Medical School, Boston,
MA

MASANORI AIKAWA, MD, PhD
Cardiovascular Division, Brigham and Women's Hospital,
Boston, MA

GARY L. BAUMBACH, MD
Department of Pathology, University of Iowa College of
Medicine, Iowa City, IA

ANDREW J. CARTER, Do
Division of Cardiovascular Medicine, Stanford University
Medical Center, Stanford, CA

RAYMOND H. CHEN, MD, DPhil
Brigham and Women's Hospital, Harvard Medical School,
Boston, MA

ZHIPING CHEN, MS
Cardiovascular Division, Brigham and Women's Hospital,
Boston, MA

BARRY S. COLLER, MD
Department of Medicine, Mount Sinai School of Medicine,
New York, NY

VICTOR J. DZAU, MD
Department of Medicine, Brigham and Women's Hospital,
Boston, MA

ELAZER R. EDELMAN, MD, PhD, FACC
Division of Health Sciences and Technology, Brigham and
Women's Hospital/Harvard-MIT, Cambridge, MA

AFSHIN EHSAN, MD
Research Institute and Department of Medicine, Brigham
and Women's Hospital, Boston, MA
DANIEL T. EITZMAN, MD
Department of Internal Medicine, University of Michigan
Medical School, Ann Arbor, MI

WILLIAM P. FAY, MD
Department of Internal Medicine, University of Michigan
Medical School, Ann Arbor, MI

JOHN D. FOLTS, PhD, FACC
Division of Cardiology, Coronary Thrombosis Research
Laboratory, University of Wisconsin-Madison Medical
School, Madison, WI

YOSHIHIRO FUKUMOTO, MD, PhD
Cardiovascular Division, Department of Medicine, Brigham
and Women's Hospital, Boston, MA

DAVID R. HOLMES, JR., MD
Division of Cardiovascular Diseases and Internal Medicine,
Mayo Clinic, Rochester, MN

JENNIFER L. HOOVER, BA
Transplantation Biology, Novartis Pharmaceuticals
Corporation, Summit, NJ

CHRISTOPHER HORVATH, DVM, Ms
Millenium Pharmaceuticals Inc., Cambridge, MA

BIRGIT KANTOR, MD
Division of Cardiovascular Diseases and Internal Medicine,
Mayo Clinic, Rochester, MN

DAVID KRITCHEVSKY, PhD
Wistar Institute, Philadelphia, PA

PETER LIBBY, MD
Cardiovascular Division, Brigham and Women's Hospital,
Boston, MA

VOLKHARD LINDNER, MD, PhD
Division of Molecular Medicine, Maine Medical Center
Research Institute, South Portland, ME

MICHAEL J. MANN, MD
Research Institute and Department of Medicine, Brigham
and Women's Hospital, Boston, MA

ROBERT P. MARINI, DVM
Division of Comparative Medicine, MIT, Cambridge, MA

BARBARA MEYRICK, PhD
Department of Pathology and Center for Lung Research,
Vanderbilt University Medical Center, Nashville, TN

RICHARD N. MITCHELL, MD, PhD
Department of Pathology, Brigham and Women's Hospital,
Boston, MA

CLAUDIO NAPOLI, MD
Department of Medicine, University of California, San
Diego, CA

MARK NEDELMAN, MS
Primedica Corporation, Worcester, MA

ROBERT J. Nicolosi, PhD
Center for Chronic Disease Control, University of
Massachusetts, Lowell, MA

WULF PALINSKI, MD
Department of Medicine, University of California, San
Diego, CA

ANDREW C. PARKER, BS
Department of lnternal Medicine, University of Michigan,
Medical School, Ann Arbor, MI

MARLENE RABINOVITCH, MD
Division of Cardiovascular Research, The Hospita, for Sick
Children, Toronto, Ontario, Canada

ELENA RABKIN, MD, PhD
Department of Pathology, Brigham and Women's Hospital,
Harvard Medical School, Boston, MA

PETER D. REAVEN, MD
Department of Endocrinology, Carl T. Hayden VAMC
Phoenix, AZ

ERNANE D. REIS, MD
Department of Surgery, Mount Sinai School of Medicine
New York, NY

CAMPBELL ROGERS, MD, FACC
Cardiovascular Division, Brigham and Women's
Hospital/Harvard-MIT, Boston, MA

ROBERT S. SCHWARTZ, MD
Division of Cardiovascular Diseases and Interna Medicine,
Mayo Clinic, Rochester, MN

PHILIP S. SEIFERT, MS, HTL (ASCP)
Health Sciences and Technology Division Biomedical
Engineering Center, MIT, Cambridge, MA

VICTOR Chengwei SHI,MD
Novartis Pharmaceuticals Corporation, Transplantation
Biology, Summit, NJ

DANIEL I. SIMON, MD
Cardiovascular Division, Brigham and Women's Hospital
Boston, MA

SUSAN S. SMYTH, MD, PhD
Department of Medicine, Mount Sinai School of Medicine
New York, NY

ELENA TCHEKN EVA, MD
Department of Pathology and Center for Lung Research,
Vanderbilt University Medical Center, Nashville, TN

FREDERICK G.P. WELT, MD
Division of Cardiology, Brigham and Women's
Hospital/Harvard-MIT, Boston, MA

RANDAL J. WESTRICK, BS
Department of Internal Medicine, University of Michigan
Medical School, Ann Arbor, MI

YANHONG ZHU, MD
Department of Internal Medicine, University of Michigan
Medical School, Ann Arbor, MI