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CONTENTS
Contributing Authors ix
Preface xi
SECTION ONE:
GENERAL CONSIDERATIONS
1. Principles of Cardiac SPECT Imaging 3
S. James Cullom
2. Quality Control for SPECT Imaging 17
Kenneth J Nichols and James R. Galt
3. Quantitative Analysis of SPECT Myocardial
Perfusion 41
Kenneth F. Tan Train, Ernest V. Garcia,
C. David Cooke, and Joseph S. Areeda
4. Advanced Computer Methods in Cardiac SPECT 65
C. David Cooke, Tracy L. Faber, Joseph S. Areeda,
and Ernest V. Garcia
5. Advances in Instrumentation for Cardiac SPECT 81
James R. Galt and Ernest V. Garcia
6. Attenuation Correction in Myocardial Perfusion
SPECT 89
S. James Cullom, James A. Case, and Timothy M.
Bateman
7. Gated Perfusion SPECT: Technical Considerations
103
Guido Germano, Kenneth J. Nichols, S. James
Cullom, Tracy L. Faber, and C. David Cooke
8. Radiopharmaceuticals 117
Raymond Taillefer
SECTION TWO:
CLINICAL CONSIDERATIONS
9. Detection, Evaluation, and Risk Stratification of
Coronary Artery Disease by Thallium-201
Myocardial Perfusion Scintigraphy 155
Jamshid Maddahi and Daniel S. Berman
10. Assessment of Myocardial Perfusion and Viability
with Technetium-99m Perfusion Agents 179
Daniel S. Berman, Sean W. Hayes, and Guido
Germano
11. Clinical Application of Gated Myocardial Perfusion
SPECT 211
E. Gordon DePuey, Gary Heller, and Raymond
Taillefer
12. Artifacts in SPECT Myocardial Perfusion Imaging
231
E. Gordon DePuey
13. Myocardial Perfusion Scintigraphy in Conjunction
with Exercise and Pharmacologic Stress:
Prognostic Applications in the Clinical Management
of Patients with Coronary Artery Disease 263
Siu-Sun Yao and Alan Rozanski
14. Cost-Effectiveness of Myocardial Perfusion SPECT
297
Rory Hachamovitch and Leslee J Shaw
15. F-18 Fluorodeoxyglucose SPECT 311
Frans C. Visser, Jeroen J Bax, and Martin P. Sandler
16. Gated Blood-Pool SPECT 321
Edward P. Ficaro and James R. Corbett
Subject Index 339
CONTRIBUTING AUTHORS
Joseph S. Areeda, B.A. Department of Nuclear Medicine,
Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los
Angeles, California 90048
Timothy M. Bateman Cardiovascular Consultants,
Mid-America Heart Institute, 4401 Wornall Road, Kansas
City, Missouri 64111
Jeroen J. Bax Cardiologist, Department of Cardiology,
Leiden University Medical Center, 2 Albinusdreef, Leiden,
2333ZA, The Netherlands
Daniel S. Berman, M.D. Professor of Medicine, UCLA
School of Medicine; Director, Nuclear Cardiology,
Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los
Angeles, California 90048
James A. Case Cardiovascular Consultants, Mid-America
Heart Institute, 4401 Wornall Road, Kansas City, Missouri
64111
C. David Cooke, M.S.E.E. Assistant Professor, Department
of Radiology Emory University School of Medicine, 1364
Clifton Road NE, Atlanta, Georgia 30322
James R. Corbett, M.D. Director, Cardiovascular Nuclear
Medicine; Professor, Department of Radiology and Internal
Medicine, University of Michigan Medical Center, 1500 E.
Medical Center Drive, Ann Arbor, Michigan 48109-0028
S. James Cullom, Ph.D. Clinical Physicist, Cardiovascular
Consultants, PC, 4330 Wornall Road, Suite 2000,
Mid-America Heart Institute, 4401 Wornall Road, Kansas
City, Missouri 64111
E. Gordon DePuey, M.D. Professor, Department of
Radiology, Columbia University College of Physicians and
Surgeons, Director, Division of Nuclear Medicine,
Department of Radiology, St. Luke's-Roosevelt Hospital,
1111 Amsterdam Avenue, New York, New York 10025
Tracy L. Faber, Ph.D. Assistant Professor of Radiology,
Division of Nuclear Medicine, Emory University School of
Medicine, 1364 Clifton Road NE, Atlanta, Georgia 30322
Edward P Ficaro, Ph.D. Assistant Research Scientist,
Department of Radiology, University of Michigan Medical
Center, 1500 East Medical Center Drive, Ann Arbor,
Michigan 48109
James R. Gait, Ph.D. Assistant Professor, Department of
Radiology, Emory University School of Medicine; Director
of Nuclear Medicine Physics, Division of Nuclear Medicine,
Emory University Hospital, 1364 Clifton Road NE, Atlanta,
Georgia 30322
Ernest V Garcia, Ph.D. Professor and Vice Chairman for
Research, Department of Radiology, Emory University
School of Medicine, 1364 Clifton Road NE, Atlanta,
Georgia 30322
Guido Germano, Ph.D. Director, Nuclear Medicine Physics,
Cedars-Sinai Medical Center; Associate Professor of
Radiological Science, University of California at Los
Angeles School of Medicine, 10833 LeConte Avenue, Los
Angeles, California 90024
Rory Hachamovitch, M.D. Co-Director, Technology
Evaluation Center; and Associate Professor, Department of
Health Policy and Management, Emory University, 1518
Clifton Road NE, Atlanta, Georgia 30322
Sean W. Hayes, M.D. Department of Cardiology/Nuclear
Medicine, Cedars-Sinai Medical Center, 8700 Beverly
Boulevard, Los Angeles, California 90048
Gary Heller Division of Nuclear Medicine, Department of
Radiology, St. Luke'sRoosevelt Hospital, 114th Street and
Amsterdam Avenue, New York, New York 10025
Jamshid Maddahi, M.D. Professor of Molecular and Medical
Pharmacology (Nuclear Medicine), University of California
at Los Angeles School of Medicine, 10833 LeConte Avenue,
Los Angeles, California 90024
Kenneth J. Nichols, Ph.D. Associate Research Scientist,
Division of Cardiology, Columbia University, 622 West
168th Street, New York, New York 10032
Alan Rozanski, M.D. Professor of Medicine, Columbia
University College of Physicians and Surgeons; and
Director, Nuclear Cardiology, St. Luke's-Roosevelt Medical
Center, 1111 Amsterdam Avenue, New York, New York
10025
Martin P Sandier Professor and Vice-Chairman, Department
of Radiology and Radiological Sciences, Vanderbilt
University School of Medicine, Nashville, Tennessee 37232
Leslee J. Shaw, Ph.D. Associate Professor, Department of
Health Policy and Management, Emory University;
Co-Director of Outcomes Research, Department of
Medicine, Emory University Hospital, 318 Woodruff
Research Building, Atlanta, Georgia 30322
Raymond Taillefer, M.D., ER.C.P, A.B.N.M. Professor,
Departments of Radiology and Nuclear Medicine,
Universit6 de Montr6al; and Chief, Department of Nuclear
Medicine, Centre Hospitalier De 1'Universite de Montreal,
H&tel-Dieu, 3840 St. Urbain, Montreal, Quebec H2W IT8,
Canada
Kenneth E Van Train, M.S. Director of Computer Research
and Development, Department of Medical Physics and
Imaging, Cedars-Sinai Medical Center, 8700 Beverly
Boulevard, Los Angeles, California 90048-1805
Frans C. Visser, M.D. Professor, Department of Cardiology,
Academic Hospital Vrye Universiteit, 1117 de Boelelaan;
Vice-Director, Institute for Cardiovascular ResearchVrye
Universiteit, 7 Vander Boechorststraat, Amsterdam 1081 BT
The Netherlands
Siu-Sun Yao Assistant Professor of Clinical Medicine,
Columbia University College of Physicians and Surgeons;
and Co-Director, Nuclear Cardiology and Cardiac Stress
Testing, St. Luke'sRoosevelt Medical Center, 1111
Amsterdam Avenue, New York, New York 10025
